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Genes Nutr. 2014 Jul;9(4):406. doi: 10.1007/s12263-014-0406-6. Epub 2014 May 20.

High-fat and obesogenic diets: current and future strategies to fight obesity and diabetes.

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  • 1Center for Neurosciences and Cell Biology, University of Coimbra, 3004-517, Coimbra, Portugal.


Obesity, diabetes and their associated diseases are some of the greatest challenges that the world health care systems already face and with prospects of overburdening their capacities and funding. Due to decreased energetic expenditure and increased caloric intake, particularly in saturated fats, the number of people afflicted by said conditions is increasing by the day. Due to the failure, to this day, to effectively and ubiquity prevent and revert these diseases, the research into new compounds and therapeutic strategies is vital. In this review, we explain the most common dietary models of obesity and diabetes and the novel avenues of research we believe will be taken in the next few years in obesity and diabetes research. We primarily focus on the role of mitochondria and how the modulation of mitochondrial function and number as well as several promising therapeutic strategies involving metabolic regulators can positively affect the obese and diabetic status.

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