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Arch Phys Med Rehabil. 2014 Oct;95(10):1824-31. doi: 10.1016/j.apmr.2014.04.024. Epub 2014 May 16.

Nonsteroidal anti-inflammatory drugs versus corticosteroid for treatment of shoulder pain: a systematic review and meta-analysis.

Author information

  • 1Department of Chemical Biology, School of Pharmaceutical Science, Peking University Health Science Center, Beijing, China.
  • 2Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • 3Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • 4Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • 5Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • 6Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: huangwei68@263.net.

Abstract

OBJECTIVE:

To compare the treatment efficacy between corticosteroid injection and nonsteroidal anti-inflammatory drugs (NSAIDs) for patients with shoulder pain.

DATA SOURCES:

PubMed and EMBASE databases were searched from inception to January 2014. Reference lists of the retrieved studies were additionally scrutinized.

STUDY SELECTION:

Randomized controlled trials (RCTs) comparing corticosteroid injection with NSAIDs for treatment of shoulder pain were included. The primary outcome was remission, and the secondary outcomes were pain relief and improvement of range of active abduction. Study selection was conducted by 2 researchers independently. Any disagreements were solved by discussion and confirmed by the third reviewer.

DATA EXTRACTION:

Two reviewers independently conducted data extraction and the quality assessment. Data regarding patients, intervention, control, and outcomes were extracted from the included trials.

DATA SYNTHESIS:

Six high-quality RCTs of 267 patients meeting the inclusion criteria were included. For an outcome of remission, NSAIDs were less effective than corticosteroid in 4 or 6 weeks (relative risk, .64; 95% confidence interval, .45-.92). NSAIDs did not significantly differ with corticosteroid in pain relief and improvement of range of active abduction.

CONCLUSIONS:

Current meta-analysis suggests that NSAIDs are less effective than corticosteroid in achieving remission in patients with shoulder pain at 4 or 6 weeks after treatment. Considering the limited number of studies and small size of each trial, the results should be interpreted with caution, and more high-quality RCTs are encouraged.

Copyright © 2014 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

KEYWORDS:

Corticosteroids; Meta-Analysis; NSAIDs; Rehabilitation; Shoulder pain

PMID:
24841629
[PubMed - indexed for MEDLINE]
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