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Talanta. 2014 Jul;125:221-6. doi: 10.1016/j.talanta.2014.02.060. Epub 2014 Mar 3.

Dopamine functionalized-CdTe quantum dots as fluorescence probes for l-histidine detection in biological fluids.

Author information

  • 1Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun 130012, China.
  • 2Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun 130012, China. Electronic address: suxg@jlu.edu.cn.

Abstract

In this paper, we developed dopamine functionalized-CdTe quantum dots as fluorescence probes for the determination of l-histidine. Firstly, CdTe was covalently linked to dopamine to form a kind of fluorescence sensor with pyrocatechol structure on the surface. The photoluminescence intensity of CdTe-dopamine (QDs-DA) could be quenched by Ni(2+) due to the strong coordination interaction between the pyrocatechol structure of QDs-DA and Ni(2+). In the presence of l-histidine, Ni(2+) preferred to bind with l-histidine due to high affinity of Ni(2+) to l-histidine and the photoluminescence intensity of QDs-DA was recovered. The recovered photoluminescence intensity of QDs-DA was proportional to the concentration of l-histidine in the ranges of 1.0×10(-6)-1.0×10(-4)mol L(-1) and the detection limit was 5.0×10(-7)mol L(-1) respectively. The established method showed a good selectivity for l-histidine among other common amino acids, and it was applied for determination of l-histidine in human serum sample with satisfactory results.

Copyright © 2014 Elsevier B.V. All rights reserved.

KEYWORDS:

Dopamine; Fluorescence; Ni(2+); Quantum dots; l-Histidine

PMID:
24840437
[PubMed - in process]
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