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Acta Paediatr. 2014 Oct;103(10):1009-18. doi: 10.1111/apa.12692. Epub 2014 Jul 28.

Safe oxygen saturation targeting and monitoring in preterm infants: can we avoid hypoxia and hyperoxia?

Author information

  • 1Ibero American Society of Neonatology (SIBEN), Dana Point, CA, USA; New York Medical College, Valhalla, NY, USA.

Abstract

Oxygen is a neonatal health hazard that should be avoided in clinical practice. In this review, an international team of neonatologists and nurses assessed oxygen saturation (SpO2 ) targeting in preterm infants and evaluated the potential weaknesses of randomised clinical trials.

CONCLUSION:

SpO2 of 85-89% can increase mortality and 91-95% can cause hyperoxia and ill effects. Neither of these ranges can be recommended, and wider intermediate targets, such as 87-94% or 88-94%, may be safer.

© 2014 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.

KEYWORDS:

Hyperoxia; Oximetry; Oxygen saturation; Premature infant; Retinopathy of prematurity

PMID:
24838096
[PubMed - indexed for MEDLINE]
PMCID:
PMC4225465
Free PMC Article
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