Format

Send to

Choose Destination
See comment in PubMed Commons below
Schizophr Res. 2014 Jul;156(2-3):157-60. doi: 10.1016/j.schres.2014.04.022. Epub 2014 May 14.

Diffusion tensor imaging study of the fornix in first episode schizophrenia and in healthy controls.

Author information

  • 1Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States. Electronic address: jfitzsimmons@bwh.harvard.edu.
  • 2Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; Department of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
  • 3Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
  • 4Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; Department of General Psychiatry, Medical University Innsbruck, Innsbruck, Austria.
  • 5Beth Israel Deaconess Medical Center, Massachusetts Mental Health Center, Public Psychiatry Division, Harvard Medical School, Boston, MA, United States; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
  • 6Beth Israel Deaconess Medical Center, Massachusetts Mental Health Center, Public Psychiatry Division, Harvard Medical School, Boston, MA, United States; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
  • 7Beth Israel Deaconess Medical Center, Massachusetts Mental Health Center, Public Psychiatry Division, Harvard Medical School, Boston, MA, United States.
  • 8Stanley Center of Psychiatry Research, Broad Institute of MIT and Harvard, Boston, MA, United States; Psychiatry and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, United States.
  • 9Surgical Planning Laboratory, MRI Division, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Abstract

BACKGROUND:

The fornix is a compact bundle of white matter fibers that project from the hippocampus to the mamillary bodies and septal nuclei. Its association with memory, as well as with symptoms in schizophrenia, has been reported in chronic schizophrenia. The purpose of this study is to determine whether or not fornix abnormalities are evident at the onset of schizophrenia.

METHODS:

Diffusion tensor imaging (DTI) and DT tractography were used to evaluate the fornix in 21 patients with first episode schizophrenia (16 males/5 females) and 22 healthy controls (13 males/9 females). Groups were matched on age, gender, parental socioeconomic status, education and handedness. Fractional anisotropy (FA), a measure of white matter integrity, radial diffusivity (RD), thought to reflect myelin integrity, trace, a possible marker of atrophy or cell loss, and axial diffusivity (AD), thought to reflect axonal integrity, were averaged over the entire tract extracted by means of DT tractography, and used to investigate fornix abnormalities in first episode schizophrenia compared with healthy controls.

RESULTS:

Significant group differences were found between first episode patients and controls for FA (p=0.0001), RD (p=0.001) and trace (p=0.006).

CONCLUSION:

These findings suggest abnormalities in the fornix in the early stages of schizophrenia, and further suggest that white matter abnormalities, which are apparent in the early course of the disease, may reflect myelin disturbances.

Copyright © 2014 Elsevier B.V. All rights reserved.

KEYWORDS:

Axial diffusivity; Diffusion tensor imaging; First episode schizophrenia; Fornix; Fractional anisotropy; Radial diffusivity; Trace

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk