Acute respiratory failure during first cyclophosphamide infusion in a patient with systemic lupus erythematosus

P Schjelderup; T C El-Galaly; J B Frøkjær; T Ring

doi:10.1007/s00393-014-1381-4

Acute respiratory failure during first cyclophosphamide infusion in a patient with systemic lupus erythematosus

Z Rheumatol. 2014 Dec;73(10):939-41. doi: 10.1007/s00393-014-1381-4.

Authors

P Schjelderup¹, T C El-Galaly, J B Frøkjær, T Ring

Affiliation

¹ Department of Nephrology, Aalborg University Hospital, Mølleparkvej 4, 9000, Aalborg, Denmark, pschjelderup@gmail.com.

PMID: 24830677
DOI: 10.1007/s00393-014-1381-4

Abstract

We present a report of what we believe was an extremely rare case of hyperacute respiratory failure caused by first time exposure to cyclophosphamide in a 40-year-old woman with systemic lupus erythematosus. The patient was extensively evaluated for alternative etiologies with negative results. Treatment with methylprednisolone and high doses of human immunoglobulin resulted in gradual improvement of the patient's condition. We review the literature with regard to cyclophosphamide-induced lung toxicity.

Publication types

Case Reports

MeSH terms

Adult
Antirheumatic Agents / administration & dosage
Antirheumatic Agents / adverse effects
Cyclophosphamide / administration & dosage*
Cyclophosphamide / adverse effects*
Female
Humans
Immunoglobulins / therapeutic use
Infusions, Intra-Arterial
Lupus Erythematosus, Systemic / complications*
Lupus Erythematosus, Systemic / drug therapy*
Methylprednisolone / therapeutic use
Respiratory Distress Syndrome / chemically induced*
Respiratory Distress Syndrome / diagnosis
Respiratory Distress Syndrome / prevention & control*
Treatment Outcome

Substances

Antirheumatic Agents
Immunoglobulins
Cyclophosphamide
Methylprednisolone