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BMJ Case Rep. 2014 May 14;2014. pii: bcr2013202912. doi: 10.1136/bcr-2013-202912.

A 'picturesque' case of transition from subcutaneous to oral treatment in neonatal diabetes.

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  • 1Department of Pediatrics, Hagaziekenhuis/Juliana Children's Hospital, The Hague, The Netherlands.


We report a case of a 6-week-old infant with diabetes mellitus based on a genetic defect in the sulfonylurea receptor 1 (SUR1), an ATP-sensitive potassium (KATP) channel protein. A spectacular improvement in glucose regulation was shown by real-time continuous glucose monitoring when switching her from insulin to oral glibenclamide. Children with neonatal onset of diabetes deserve genetic testing in order to replace insulin with oral medication.

2014 BMJ Publishing Group Ltd.

[PubMed - indexed for MEDLINE]
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