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Biochem J. 1989 Dec 15;264(3):765-9.

Antibodies against the non-muscle isoform of the endoplasmic reticulum Ca2(+)-transport ATPase.

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  • 1Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, Belgium.


We report here the production of a polyclonal antiserum which specifically recognizes an epitope confined to the ultimate 12-residue-long C-terminus of an alternatively spliced transcript of gene 2 encoding the sarcoplasmic reticulum Ca2+ pump in slow skeletal and cardiac muscle. This alternatively spliced transcript was shown to be mainly represented in non-muscle tissues. These antibodies have enabled us to show the presence of the unique C-terminus of this type of Ca2+ pump, as predicted from the cDNA sequence, in the endoplasmic reticulum of vascular and gastric smooth muscle, liver and kidney.

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