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J Autism Dev Disord. 2014 Nov;44(11):2742-54. doi: 10.1007/s10803-014-2131-9.

White matter microstructure predicts autistic traits in attention-deficit/hyperactivity disorder.

Author information

  • 1Child and Adolescent Psychiatry Section, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Second Floor, Hadyn Ellis Building, Maindy Road, Cathays, Cardiff, CF24 4HQ, UK, cooperml1@cardiff.ac.uk.

Erratum in

  • J Autism Dev Disord. 2014 Nov;44(11):2755.

Abstract

Traits of autism spectrum disorder (ASD) in children with attention-deficit/hyperactivity disorder (ADHD) have previously been found to index clinical severity. This study examined the association of ASD traits with diffusion parameters in adolescent males with ADHD (n = 17), and also compared WM microstructure relative to controls (n = 17). Significant associations (p < 0.05, corrected) were found between fractional anisotropy/radial diffusivity and ASD trait severity (positive and negative correlations respectively), mostly in the right posterior limb of the internal capsule/corticospinal tract, right cerebellar peduncle and the midbrain. No case-control differences were found for the diffusion parameters investigated. This is the first report of a WM microstructural signature of autistic traits in ADHD. Thus, even in the absence of full disorder, ASD traits may index a distinctive underlying neurobiology in ADHD.

PMID:
24827086
[PubMed - indexed for MEDLINE]
PMCID:
PMC4194020
Free PMC Article
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