Antigenuria in chronic chagasic patients detected by a monoclonal antibody raised against Trypanosoma cruzi

A Katzin; M J Alves; G Abuin; W Colli

doi:10.1016/0035-9203(89)90497-5

Antigenuria in chronic chagasic patients detected by a monoclonal antibody raised against Trypanosoma cruzi

Trans R Soc Trop Med Hyg. 1989 May-Jun;83(3):341-3. doi: 10.1016/0035-9203(89)90497-5.

Authors

A Katzin¹, M J Alves, G Abuin, W Colli

Affiliation

¹ Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Brazil.

PMID: 2482556
DOI: 10.1016/0035-9203(89)90497-5

Abstract

A monoclonal antibody (B2/5) raised against Trypanosoma cruzi was able to immunoprecipitate a major 100 kDa polypeptide in 84% of the urines collected from chronic chagasic patients. Other polypeptides were also detected. The antibody recognized polypeptides on the surface of epimastigotes (150-25 kDa) and metacyclic trypomastigotes (150-50 kDa), suggesting that the antigens share a common epitope.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Animals
Antibodies, Monoclonal
Antibodies, Protozoan
Antigens, Protozoan / immunology
Antigens, Protozoan / urine*
Antigens, Surface / immunology
Antigens, Surface / urine
Chagas Disease / immunology*
Chagas Disease / urine
Chronic Disease
Epitopes
Female
Humans
Male
Middle Aged
Trypanosoma cruzi / immunology*

Substances

Antibodies, Monoclonal
Antibodies, Protozoan
Antigens, Protozoan
Antigens, Surface
Epitopes