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PLoS One. 2014 May 9;9(5):e96792. doi: 10.1371/journal.pone.0096792. eCollection 2014.

Interleukin-27 is differentially associated with HIV viral load and CD4+ T cell counts in therapy-naïve HIV-mono-infected and HIV/HCV-co-infected Chinese.

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  • 1Stanley Ho Center for Emerging Infectious Diseases, School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong SAR, China.
  • 2Stanley Ho Center for Emerging Infectious Diseases, School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong SAR, China; Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
  • 3Division of Biostatistics, School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong SAR, China.
  • 4Division of Biosciences, Faculty of Life Science, University College London, London, United Kingdom.
  • 5Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
  • 6Division of Digestive Diseases, West China Hospital, Sichuan University, Chengdu, China.
  • 7Stanley Ho Center for Emerging Infectious Diseases, School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong SAR, China; Li Ka Shing Institute of Health Sciences, School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong SAR, China.

Abstract

Human Immunodeficiency Virus (HIV) infection and the resultant Acquired Immunodeficiency Syndrome (AIDS) epidemic are major global health challenges; hepatitis C virus (HCV) co-infection has made the HIV/AIDS epidemic even worse. Interleukin-27 (IL-27), a cytokine which inhibits HIV and HCV replication in vitro, associates with HIV infection and HIV/HCV co-infection in clinical settings. However, the impact of HIV and HCV viral loads on plasma IL-27 expression levels has not been well characterized. In this study, 155 antiretroviral therapy-naïve Chinese were recruited. Among them 80 were HIV- and HCV-negative healthy controls, 45 were HIV-mono-infected and 30 were HIV/HCV-co-infected. Plasma level HIV, HCV, IL-27 and CD4+ number were counted and their correlation, regression relationships were explored. We show that: plasma IL-27 level was significantly upregulated in HIV-mono-infected and HIV/HCV-co-infected Chinese; HIV viral load was negatively correlated with IL-27 titer in HIV-mono-infected subjects whereas the relationship was opposite in HIV/HCV-co-infected subjects; and the relationships between HIV viral loads, IL-27 titers and CD4+ T cell counts in the HIV mono-infection and HIV/HCV co-infection groups were dramatically different. Overall, our results suggest that IL-27 differs in treatment-naïve groups with HIV mono-infections and HIV/HCV co-infections, thereby providing critical information to be considered when caring and treating those with HIV mono-infection and HIV/HCV co-infection.

PMID:
24816922
[PubMed - indexed for MEDLINE]
PMCID:
PMC4016030
Free PMC Article
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