Format

Send to:

Choose Destination
See comment in PubMed Commons below
Immunol Res. 2014 Aug;59(1-3):23-34. doi: 10.1007/s12026-014-8527-y.

Functions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement.

Author information

  • 1Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, 52242, USA.

Abstract

T cells control the focus and extent of adaptive immunity in infectious and pathological diseases. The activation of T cells occurs when the T cell antigen receptor (TCR) and costimulatory and/or adhesion receptors are engaged by their ligands. This process drives signaling that promotes cytoskeletal rearrangement and transcription factor activation, both of which regulate the quality and magnitude of the T cell response. However, it is not fully understood how different receptor-induced signals combine to alter T cell activation. The related non-receptor tyrosine kinases focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) are phosphorylated downstream of the TCR and several costimulatory and adhesion receptors. FAK family proteins integrate receptor-mediated signals that influence actin cytoskeletal rearrangement and effector T cell responses. In this review, we summarize the receptor-specific roles that FAK and Pyk2 control to influence T cell development and activation.

PMID:
24816556
[PubMed - indexed for MEDLINE]
PMCID:
PMC4125427
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Write to the Help Desk