Format

Send to:

Choose Destination
See comment in PubMed Commons below
In Vivo. 2014 May-Jun;28(3):273-85.

Melanoma m1: diagnosis and therapy.

Author information

  • 1Melanoma and Sarcoma Unit, Veneto Institute of Oncology IOV-IRCCS Padova, Italy. marco.rastrelli@ioveneto.it.

Abstract

This article reviews the epidemiology, pathogenesis, diagnosis, prognostic factors and treatment of metastatic melanoma, including the most recent developments in the specific field. It examines the sequential and non-linear models of development and progression of melanoma and the main molecular disorder involved in these processes. Clinical and diagnostic aspects have been divided according to clinical staging. Surgical resectability, the site and number of metastases, the number of involved organs, the duration of remission, serum lactate dehydrogenase levels and tumor doubling-time have the greatest prognostic value. Surgical treatment has been analyzed considering its rational function and examining all sites involved in metastasis. We also discuss the palliative role of radiotherapy in relation to various metastatic sites, chemotherapy and recently introduced targeted-therapy. The association of newer drugs and new biological therapies such as ipilimumab and verumafenib have improved the treatment landscape of stage IV melanoma.

KEYWORDS:

Stage IV melanoma; chemotherapy; radiotherapy; review; surgery; tumor doubling-time

PMID:
24815827
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk