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Evid Based Complement Alternat Med. 2014;2014:407509. doi: 10.1155/2014/407509. Epub 2014 Apr 9.

Effect of "jian-pi-zhi-dong decoction" on gamma-aminobutyric Acid in a mouse model of tourette syndrome.

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  • 1Department of Pediatrics, Dongfang Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100078, China ; School of Nursing, Taishan Medical University, Taian 271016, China.
  • 2Department of Pediatrics, Dongfang Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100078, China.

Abstract

The purpose of this study was to explore the positive effects of Jian-Pi-Zhi-Dong Decoction (JPZDD) on Tourette syndrome (TS) by investigating the expression of gamma-aminobutyric acid (GABA) and its type A receptor (GABAAR) in the striatum of a TS mice model. The model was induced by 3,3'-iminodipropionitrile (IDPN) treatment; then mice were divided into 4 groups (n=22, each); control and IDPN groups were gavaged with saline and the remaining 2 groups were gavaged with tiapride and JPZDD. We recorded the stereotypic behaviors of TS mice and measured the content of GABA in striatum by HPLC and GABAAR expression by immunohistochemistry and real-time PCR. Our results showed that JPZDD inhibited the abnormal behaviors of TS model mice and decreased GABA levels and GABAAR protein and mRNA expression in the striatum of TS model mice. In brief, the mechanism by which JPZDD alleviates TS symptoms may be associated with GABAAR expression downregulation in striatum which may regulate GABA metabolism.

PMID:
24812567
[PubMed]
PMCID:
PMC4000640
Free PMC Article
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