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Raymond Purves Research Laboratories, Royal North Shore Hospital of Sydney, St. Leonards, Australia.
The intraarticular injection of a sterile solution of 25 mg hydrocortisone succinate into rabbit knee joints once a week for 8 weeks reduced the levels of proteoglycans and hyaluronic acid (HA) in articular cartilage. In contrast, the keratan sulfate (KS) peptide levels present in sera of these animals were elevated relative to a saline treated control group. By injecting 25 mg hydrocortisone succinate combined with pentosan polysulfate (Cartrophen) (5 mg) into rabbit joints over the 8 week period, the loss of proteoglycans and HA from articular cartilage was abrogated and serum KS-peptides were restored, with time, to within control levels. These findings suggest that intraarticular administration of high dose hydrocortisone succinate to rabbits has a deleterious effect on articular cartilage HA and proteoglycan metabolism but this effect can be attenuated by co-intraarticular administration of Cartrophen.
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