Format

Send to:

Choose Destination
See comment in PubMed Commons below
Int J Cardiol. 2014 Jul 1;174(3):696-701. doi: 10.1016/j.ijcard.2014.04.221. Epub 2014 Apr 26.

Systematic review and meta-analysis of incidence and correlates of recurrence of takotsubo cardiomyopathy.

Author information

  • 1Dept. of Cardiology, Queen Elizabeth Hospital, University of Adelaide, Adelaide, SA 5000, Australia. Electronic address: kjaulakh@gmail.com.
  • 2Dept. of Respiratory Medicine, Basil Hetzel Institute, University of Adelaide, Adelaide, SA 5000, Australia.
  • 3The Madison Practice, Suite 6, 25 Hunter St., Hornsby, NSW 2077, Australia.
  • 4Dept. of Cardiology, Queen Elizabeth Hospital, University of Adelaide, Adelaide, SA 5000, Australia.

Abstract

AIM:

Takotsubo cardiomyopathy (TTC) is a disorder of myocardial inflammation induced by high catecholamine levels and is associated with acute complications. In the long-term TTC is associated with a risk of single or multiple recurrences, but risk of such occurrences is not clear. We performed a systematic review and meta-analysis to identify and consolidate the evidence on the incidence and clinical correlates of cases of TTC recurrence.

METHODS:

A comprehensive search of four major databases (EMBASE, OVID Medline, PubMed and Google Scholar) was performed from their inception to first week of Jan 2014. We included original research studies, recruiting ≥ 5 participants, with ≥ 3 months follow-up, published in English language that reported data on recurrence in patients with TTC.

RESULTS:

Out of 298 studies searched, 31 cohorts (1664 TTC patients) were included in the analyses. Out of 74 cases of recurrence, with a mean follow-up of 24.5 months (95% CI, 19.3 to 33 months), extensive recurrence data were available for 23 cases. Cumulative incidence of recurrence was approximately 5% at 6 years. Annual rate of recurrence was approximately 1.5%. Furthermore, 14% of cases had recurrent chest pain and 11% reported dyspnea without definite evidence of recurrent TTC. Discharge medications at index admission included β-adrenoceptor antagonists (BB) in 66.8% and ACE inhibitors (ACEi) and ARB in 67.4%. Recurrence rate was independent of clinic utilization of BB prescription, but inversely correlated (r=-0.45, p=0.016) with ACEi/ARB prescription. Patients with severe TTC at index admission were noted to have more recurrences.

CONCLUSIONS:

(1) TTC is associated with only 1-2% annual recurrence rate but substantially greater frequency of ongoing symptoms. (2) ACEi/ARB rather than BB may reduce risk of recurrence.

Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Recurrence; Stress cardiomyopathy; Takotsubo cardiomyopathy

PMID:
24809923
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk