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Exp Neurol. 2014 Jul;257:114-9. doi: 10.1016/j.expneurol.2014.04.017. Epub 2014 May 5.

Intermittent fasting attenuates inflammasome activity in ischemic stroke.

Author information

  • 1Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland, Australia.
  • 2School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland, Australia.
  • 3School of Pharmacy, Sungkyunkwan University, Suwon, South Korea.
  • 4Department of Physiology, Georgia Health Sciences University, Augusta, GA, USA.
  • 5Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD, USA.
  • 6Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; School of Pharmacy, Sungkyunkwan University, Suwon, South Korea; School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland, Australia. Electronic address: phstva@nus.edu.sg.

Abstract

Recent findings have revealed a novel inflammatory mechanism that contributes to tissue injury in cerebral ischemia mediated by multi-protein complexes termed inflammasomes. Intermittent fasting (IF) can decrease the levels of pro-inflammatory cytokines in the periphery and brain. Here we investigated the impact of IF (16h of food deprivation daily) for 4months on NLRP1 and NLRP3 inflammasome activities following cerebral ischemia. Ischemic stroke was induced in C57BL/6J mice by middle cerebral artery occlusion, followed by reperfusion (I/R). IF decreased the activation of NF-κB and MAPK signaling pathways, the expression of NLRP1 and NLRP3 inflammasome proteins, and both IL-1β and IL-18 in the ischemic brain tissue. These findings demonstrate that IF can attenuate the inflammatory response and tissue damage following ischemic stroke by a mechanism involving suppression of NLRP1 and NLRP3 inflammasome activity.

Copyright © 2014 Elsevier Inc. All rights reserved.

KEYWORDS:

Inflammasomes; Intermittent fasting; Ischemic stroke; NLRP1; NLRP3

PMID:
24805069
[PubMed - indexed for MEDLINE]
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