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Biochim Biophys Acta. 2014 Sep;1841(9):1272-84. doi: 10.1016/j.bbalip.2014.04.009. Epub 2014 May 5.

Ancestral genetic complexity of arachidonic acid metabolism in Metazoa.

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  • 1Department of Biochemistry, College of Life Sciences, State Key Laboratory of Biocontrol, National Engineering Research Center of South China Sea Marine Biotechnology, Sun Yat-sen University, Guangzhou, 510275, People's Republic of China.
  • 2Department of Biochemistry, College of Life Sciences, State Key Laboratory of Biocontrol, National Engineering Research Center of South China Sea Marine Biotechnology, Sun Yat-sen University, Guangzhou, 510275, People's Republic of China; Beijing University of Chinese Medicine, 11 Bei San Huang Dong Road, Chao-yang District, Beijing, 100029, People's Republic of China. Electronic address: lssxal@mail.sysu.edu.cn.

Abstract

Eicosanoids play an important role in inducing complex and crucial physiological processes in animals. Eicosanoid biosynthesis in animals is widely reported; however, eicosanoid production in invertebrate tissue is remarkably different to vertebrates and in certain respects remains elusive. We, for the first time, compared the orthologs involved in arachidonic acid (AA) metabolism in 14 species of invertebrates and 3 species of vertebrates. Based on parsimony, a complex AA-metabolic system may have existed in the common ancestor of the Metazoa, and then expanded and diversified through invertebrate lineages. A primary vertebrate-like AA-metabolic system via cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) pathways was further identified in the basal chordate, amphioxus. The expression profiling of AA-metabolic enzymes and lipidomic analysis of eicosanoid production in the tissues of amphioxus supported our supposition. Thus, we proposed that the ancestral complexity of AA-metabolic network diversified with the different lineages of invertebrates, adapting with the diversity of body plans and ecological opportunity, and arriving at the vertebrate-like pattern in the basal chordate, amphioxus.

Copyright © 2014 Elsevier B.V. All rights reserved.

KEYWORDS:

COX; CYP; Eicosanoid; LOX; Molecular evolution; Phylogenetic

[PubMed - indexed for MEDLINE]
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