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Nat Prod Res. 2014;28(14):1058-64. doi: 10.1080/14786419.2014.905559. Epub 2014 May 7.

A new triterpenoid saponin and an oligosaccharide isolated from the fruits of Sapindus mukorossi.

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  • 1a School of Pharmaceutical Sciences, Sun Yat-sen University , 132 Waihuan Rd East, Panyu, Guangzhou 510006 , P.R. China.

Abstract

A new triterpenoid saponin (1) and a new oligosaccharide (2), together with three known saponins (3-5), have been isolated from n-BuOH extract of the fruits of Sapindus mukorossi Gaertn. The structures were elucidated using detailed analysis of one- and two-dimensional nuclear magnetic resonance spectra along with their mass spectrometric data and the results of acid hydrolysis. Of the isolated compounds 1 and 3-5 displayed cytotoxic effects against human cancer cell lines in A-549 (lung carcinoma), MDA-231 (breast carcinoma) and PC-3 (prostatic carcinoma).

KEYWORDS:

Sapindus mukorossi; cytotoxicity; oligosaccharide; triterpene saponin

PMID:
24800793
[PubMed - indexed for MEDLINE]
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