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J Public Health (Oxf). 2015 Sep;37(3):529-39. doi: 10.1093/pubmed/fdu026. Epub 2014 May 5.

A retrospective analysis of the cost of hospitalizations for sickle cell disease with crisis in England, 2010/11.

Author information

  • 1Business School, Imperial College, London SW72AZ, UK.
  • 2Department of Primary Care and Public Health, Imperial College, London W6 8RP, UK.
  • 3NIHR CLAHRC for Northwest London, Imperial College, London SW10 9NH, UK.



Sickle cell disease (SCD) is an inherited blood disorder which may result in a broad range of complications including recurring and severe episodes of pain--sickle 'crises'--which require frequent hospitalizations. We assessed the cost of hospitalizations associated with SCD with crisis in England.


Hospital Episodes Statistics data for all hospital episodes in England between 2010 and 2011 recording Sickle Cell Anaemia with Crisis as primary diagnosis were used. The total cost of admissions and exceeded length of stay due to SCD were assessed using Healthcare Resource Groups tariffs. The impact of patients' characteristics on SCD admissions costs and the likelihood of incurring extra bed days were also examined.


In 2010-11, England had 6077 admissions associated with SCD with crisis as primary diagnosis. The total cost for these admissions for commissioners was £18,798 255. The cost of admissions increases with age (children admissions costs 50% less than adults). Patients between 10 and 19 years old are more likely to stay longer in hospital compared with others.


SCD represents a significant cost for commissioners and the NHS. Further work is required to assess how best to manage patients in the community, which could potentially lead to a reduction in hospital admissions and length of stay, and their associated costs.

© The Author 2014. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail:


chronic disease; costs; hospitalization; management and policy; public health; sickle cell

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