Serpins shield tumor cells from antimetastatic brain defenses

Cancer Discov. 2014 May;4(5):OF17. doi: 10.1158/2159-8290.CD-RW2014-057. Epub 2014 Mar 13.

Abstract

Serpin expression in tumors facilitates brain metastasis by blocking the effects of plasmin.

MeSH terms

  • Animals
  • Brain Neoplasms / etiology
  • Brain Neoplasms / pathology*
  • Brain Neoplasms / secondary*
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology
  • Female
  • Fibrinolysin / metabolism*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology
  • Serpins / metabolism*

Substances

  • Serpins
  • Fibrinolysin