Graphene-based nanobiocatalytic systems: recent advances and future prospects

Ioannis V Pavlidis; Michaela Patila; Uwe T Bornscheuer; Dimitrios Gournis; Haralambos Stamatis

doi:10.1016/j.tibtech.2014.04.004

Graphene-based nanobiocatalytic systems: recent advances and future prospects

Trends Biotechnol. 2014 Jun;32(6):312-20. doi: 10.1016/j.tibtech.2014.04.004. Epub 2014 May 1.

Authors

Ioannis V Pavlidis¹, Michaela Patila², Uwe T Bornscheuer³, Dimitrios Gournis⁴, Haralambos Stamatis⁵

Affiliations

¹ Laboratory of Biotechnology, Department of Biological Applications and Technologies, University of Ioannina, 45110, Ioannina, Greece; Institute of Biochemistry, Department of Biotechnology and Enzyme Catalysis, University of Greifswald, Felix-Hausdorff-Str. 4, D-17487, Greifswald, Germany.
² Laboratory of Biotechnology, Department of Biological Applications and Technologies, University of Ioannina, 45110, Ioannina, Greece.
³ Institute of Biochemistry, Department of Biotechnology and Enzyme Catalysis, University of Greifswald, Felix-Hausdorff-Str. 4, D-17487, Greifswald, Germany.
⁴ Department of Material Sciences and Engineering, University of Ioannina, 45110, Ioannina, Greece.
⁵ Laboratory of Biotechnology, Department of Biological Applications and Technologies, University of Ioannina, 45110, Ioannina, Greece. Electronic address: hstamati@cc.uoi.gr.

PMID: 24794165
DOI: 10.1016/j.tibtech.2014.04.004

Abstract

Graphene-based nanomaterials are particularly useful nanostructured materials that show great promise in biotechnology and biomedicine. Owing to their unique structural features, exceptional chemical, electrical, and mechanical properties, and their ability to affect the microenvironment of biomolecules, graphene-based nanomaterials are suitable for use in various applications, such as immobilization of enzymes. We present the current advances in research on graphene-based nanomaterials used as novel scaffolds to build robust nanobiocatalytic systems. Their catalytic behavior is affected by the nature of enzyme-nanomaterial interactions and, thus, the availability of methods to couple enzymes with nanomaterials is an important issue. We discuss the implications of such interactions along with future prospects and possible challenges in this rapidly developing area.

Keywords: biofuel cells; enzyme immobilization; enzyme–nanomaterial interactions; graphene-based nanomaterials; nanobiocatalysis.

Publication types

Review

MeSH terms

Bioreactors*
Enzymes, Immobilized / chemistry
Graphite / chemistry*
Humans
Nanostructures / chemistry*
Nanotechnology / methods*

Substances

Enzymes, Immobilized
Graphite