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Am J Cardiol. 2014 Jun 15;113(12):2002-6. doi: 10.1016/j.amjcard.2014.03.042. Epub 2014 Apr 1.

Impact of female gender on bleeding complications after transradial coronary intervention (from the Korean Transradial Coronary Intervention registry).

Author information

  • 1Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
  • 2Department of Cardiology, Ajou University School of Medicine, Suwon, Korea. Electronic address:
  • 3Department of Cardiology, Yonsei University Wonju Christian Hospital, Wonju, Korea.
  • 4Department of Cardiology, Kangwon National University Hospital, Chuncheon, Korea.
  • 5Department of Cardiology, Pusan National University Hospital, Busan, Korea.
  • 6Department of Cardiology, Hallym University Kandong Scared Heart Hospital, Seoul, Korea.
  • 7Department of cardiology, Soonchunhyang University Seoul Hospital, Seoul, Korea.
  • 8Department of Cardiology, Korea University Guro Hospital, Seoul, Korea.
  • 9Department of Cardiology, Inje University Sanggye Paik Hospital, Goyang, Korea.
  • 10Department of Cardiology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
  • 11Department of Cardiology, Inha University Hospital, Incheon, Korea.
  • 12Department of Cardiology, Ulsan University GangNeung Asan Hospital, Gangneung, Korea.
  • 13Department of Cardiology, Chonnam National University Hospital, Gwangju, Korea.


Besides poor clinical outcomes, female gender has been known as a high-risk factor for bleeding complications. This study aimed to investigate the impact of gender on clinical outcomes and bleeding complications after transradial coronary intervention (TRI). The Korean TRI registry is a retrospective multicenter registry with 4,890 patients who underwent percutaneous coronary intervention in 2009 at 12 centers. To compare clinical outcomes and bleeding complications between the male and female groups, we performed a propensity score matching in patients who received TRI. A total of 1,194 patients (597 in each group) were studied. The primary outcome was 1-year major adverse cardiac events, including all-cause mortality, myocardial infarction, target vessel revascularization, and stroke. The secondary outcome was major bleeding (composite of bleeding requiring transfusion of ≥2 units of packed cells or bleeding that was fatal). The proportion of major adverse cardiac events was similar between the 2 groups (6.2% vs 4.7%, p = 0.308). The female group had a greater incidence of major bleeding (0.3% vs 3.2%, p <0.001). On multivariate analysis, female gender (odds ratio [OR] 7.748, 95% confidence interval [CI] 1.767 to 13.399), age ≥75 years (OR 5.824, 95% CI 2.085 to 16.274), and chronic kidney disease (OR 7.264, 95% CI 2.369 to 12.276) were independent predictors of major bleeding. In conclusion, the female gender had a tendency for more bleeding complications than male gender after TRI without difference in the clinical outcome.

Copyright © 2014 Elsevier Inc. All rights reserved.

[PubMed - indexed for MEDLINE]
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