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J Clin Pharmacol. 1989 Sep;29(9):821-3.

Stevens-Johnson syndrome, respiratory distress and acute renal failure due to synergic bleomycin-cisplatin toxicity.

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  • 1Department of Internal Medicine, Hospital de Clínicas José de San Martin, School of Medicine, University of Buenos Aires, Argentina.


A patient presenting with a cervix uteri epidermoid carcinoma had acute renal failure after treatment with cisplatin and bleomycin. She later developed fatal bleomycin-induced pneumonitis and Stevens-Johnson syndrome. This is a very rare association of adverse effects. The risk of causing a drug interaction thus increasing the severity of bleomycin undesired effects must be taken into account when a nephrotoxic drug is added to the former. The authors stress the importance of monitoring renal function under these conditions.

[PubMed - indexed for MEDLINE]
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