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Drug Dev Ind Pharm. 2015 Jun;41(6):934-41. doi: 10.3109/03639045.2014.914529. Epub 2014 May 2.

Preparation and evaluation of orally disintegrating tablets of taste masked phencynonate HCl using ion-exchange resin.

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  • 1Department of Pharmaceutics, Beijing Institute of Pharmacology and Toxicology , Beijing , China and.


This study was intended to design an orally disintegrating tablet (ODT) formulation that can mask the extremely bitter and metallic taste of phencynonate HCl by novel ion-exchange resins. The drug-resin complexes (DRCs) were prepared and characterized by scanning electron microscopy, X-ray powder diffraction and differential scanning calorimetry. In vitro properties (dissolution, wetting time and disintegration time) and in vivo behavior (disintegration time and taste-masking effect) in healthy volunteers of the prepared ODTs were also investigated. The drug was changed from the crystal structure to the amorphous form in the DRC. Compared with commercial tablets, the in vitro and in vivo disintegration of optimized DRC-loaded ODTs with a drug-resin ratio of 1:1 was greatly improved and better palatability with a low bitterness index (0.33) was obtained. The current DRC-loaded ODT could promise a good way to mask the unpleasant taste of certain drugs and accordingly improve the patient compliance.


Bitterness index; ion-exchange resin; orally disintegrating tablet; phencynonate HCl; taste masking

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