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Nephrol Dial Transplant. 2014 Nov;29(11):2099-105. doi: 10.1093/ndt/gfu101. Epub 2014 Apr 29.

Association of fibroblast growth factor-23 with arterial stiffness in the Multi-Ethnic Study of Atherosclerosis.

Author information

  • 1Division of General Internal Medicine, San Francisco VA Medical Center, University of California, San Francisco, CA, USA.
  • 2Department of Biostatistics, University of Washington, Seattle, WA, USA.
  • 3Division of Nephrology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
  • 4Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA, USA.

Abstract

BACKGROUND:

Serum fibroblast growth factor-23 (FGF-23) is associated with cardiovascular disease (CVD), yet the mechanisms remain uncertain. Our objective was to determine whether higher FGF-23 concentrations are associated with arterial stiffness.

METHODS:

In this cross-sectional study, serum FGF-23 concentrations were measured in 5977 participants without known CVD in the Multi-Ethnic Study of Atherosclerosis. The primary outcomes of interest were large (LAE) and small artery elasticity (SAE), pulse pressure and ankle-brachial index (ABI) > 1.30. LAE and SAE were measured by pulse contour analysis of the radial artery. Pulse pressure was measured with an automated sphygmomanometer using the average of two resting blood pressure measurements. ABI was calculated as the ratio of the ankle and brachial systolic blood pressures.

RESULTS:

Serum FGF-23 concentrations were not significantly associated with LAE [relative difference (RD) per doubling: 0%; 95% confidence interval (CI): -2-1%], SAE (RD per doubling: 0%; 95% CI: -3-2%), pulse pressure (β per doubling: 0.44; 95% CI: -0.31-1.19), or a high ABI (odds ratio per doubling: 1.14; 95% CI: 0.84-1.55). Findings were similar irrespective of chronic kidney disease status.

CONCLUSIONS:

Higher serum FGF-23 concentrations are not associated with arterial stiffness, as measured by pulse pressure, LAE, SAE or high ABI, in a community-based population without CVD.

Published by Oxford University Press on behalf of ERA-EDTA 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.

KEYWORDS:

ABI; FGF-23; arterial elasticity; arterial stiffness; pulse pressure

Comment in

PMID:
24782533
[PubMed - indexed for MEDLINE]
PMCID:
PMC4209876
[Available on 2015-11-01]
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