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[In vitro effect of psychotropic drugs on the activity of leukocyte elastase].

[Article in Russian]

Abstract

OBJECTIVE:

To investigate the effect of the neuroleptic aminazine (chlorpromazine) and the antidepressant melipramine on the activity of leukocyte elastase (LE).

METHODS:

The LE activity was measured on a spectrophotometer. Different doses of aminazine and melipramine in terms of therapeutic doses were added to the pooled blood serum sampled from 7 healthy people.

RESULTS:

Aminazine and melipramine inhibited the LE activity.

CONCLUSIONS:

The dose-dependent inhibiting effect of aminazine and melipramine was shown.

PMID:
24781228
[PubMed - indexed for MEDLINE]
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