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Nature. 1989 Oct 19;341(6243):619-24.

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1.

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  • 1Center for Blood Research, Boston, Massachusetts.


Effective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechanism between lymphocyte function-associated molecule-1 (LFA-1) and intercellular adhesion molecules (ICAMs), with intracellular signals transmitted from the T-cell antigen receptor to the LFA-1 adhesion molecule. The increase in avidity is rapid and transient, providing a dynamic mechanism for antigen-specific regulation of lymphocyte adhesion and de-adhesion.

[PubMed - indexed for MEDLINE]
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