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Nutr Res. 2014 Apr;34(4):285-93. doi: 10.1016/j.nutres.2014.02.001. Epub 2014 Feb 10.

Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicts reduced probability of polychlorinated biphenyl-associated risk for type 2 diabetes: National Health and Nutrition Examination Survey 2003-2004.

Author information

  • 1Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40506.
  • 2Department of Statistics, University of Kentucky, Lexington, KY 40506.
  • 3Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40506; Molecular and Cell Nutrition Laboratory, University of Kentucky, Lexington, KY 40506.
  • 4Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40506; Department of Dietetics and Human Nutrition, University of Kentucky, Lexington, KY 40506. Electronic address: lgaetke@email.uky.edu.

Abstract

Type 2 diabetes has been shown to occur in response to environmental and genetic influences, among them nutrition; food intake patterns; sedentary lifestyle; body mass index; and exposure to persistent organic pollutants, such as polychlorinated biphenyls (PCBs). Nutrition is essential in the prevention and management of type 2 diabetes and has been shown to modulate the toxicity of PCBs. Serum carotenoid concentrations, considered a reliable biomarker of fruit and vegetable intake, are associated with the reduced probability of chronic diseases, such as type 2 diabetes and cardiovascular disease. Our hypothesis is that fruit and vegetable intake, reflected by serum carotenoid concentrations, is associated with the reduced probability of developing type 2 diabetes in US adults with elevated serum concentrations of PCBs 118, 126, and 153. This cross-sectional study used the Center for Disease Control and Prevention database, National Health and Nutrition Examination Survey 2003-2004, in logistic regression analyses. Overall prevalence of type 2 diabetes was approximately 11.6% depending on the specific PCB. All 3 PCBs were positively associated with the probability of type 2 diabetes. For participants at higher PCB percentiles (eg, 75th and 90th) for PCB 118 and 126, increasing serum carotenoid concentrations were associated with a smaller probability of type 2 diabetes. Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicted notably reduced probability of dioxin-like PCB-associated risk for type 2 diabetes.

Copyright © 2014 Elsevier Inc. All rights reserved.

KEYWORDS:

Environmental health; NHANES, type 2 diabetes; Nutrition; Polychlorinated biphenyls, PCBs; Serum carotenoids

PMID:
24774064
[PubMed - indexed for MEDLINE]
PMCID:
PMC4008967
Free PMC Article
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