Objective: We conducted a meta-analysis of case-control studies to evaluate whether Cx37 C1019T (rs1764391 C>T) polymorphism may be implicated in the pathogenesis of coronary heart disease (CHD).
Methods: The MEDLINE (1966-2013), the Cochrane Library Database (Issue 12, 2013), EMBASE (1980-2013), CINAHL (1982-2013), Web of Science (1945-2013), and the Chinese Biomedical Database (CBM) (1982-2013) were searched without language restrictions. Meta-analysis was performed with the use of the STATA statistical software. Odds ratios (ORs) with their 95% confidence intervals (95% CIs) were calculated.
Results: Nine case-control studies with a total of 1426 CHD patients and 929 healthy controls met the inclusion criteria. Our results revealed that Cx37 C1019T polymorphism might be significantly correlated with the risk of CHD (T allele vs. C allele: OR=1.63, 95% CI=1.20-2.21, p=0.002; CT+TT vs. CC: OR=1.86, 95% CI=1.28-2.69, p=0.001; TT vs. CC+CT: OR=1.81, 95% CI=1.24-2.64, p=0.002; TT vs. CC: OR=2.50, 95% CI=1.46-4.27, p=0.001; TT vs. CT: OR=1.53, 95% CI=1.12-2.09, p=0.008; respectively). Further subgroup analysis by country indicated that Cx37 C1019T polymorphism might be closely linked to an increased risk of CHD among Chinese populations, while no positive associations were observed among non-Chinese populations (all p>0.05).
Conclusion: Our findings provide empirical evidence that Cx37 C1019T polymorphism may contribute to the pathogenesis of CHD, especially among Chinese populations.