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Transplant Proc. 2014 Apr;46(3):672-4. doi: 10.1016/j.transproceed.2013.11.021.

Corrected flow time is a good indicator for preload responsiveness during living donor liver donation.

Author information

  • 1Department of Anesthesiology, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan.
  • 2Department of Anesthesiology, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan; College of Medicine, Chang Gung University, Tao-Yuan, Taiwan; Graduate Institute of Clinical Medical Sciences, Chang Gung University, Tao-Yuan, Taiwan.
  • 3Graduate Institute of Clinical Medical Sciences, Chang Gung University, Tao-Yuan, Taiwan; Division of Transplantation and Liver Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan; Department of General Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan.
  • 4Department of Anesthesiology, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan; College of Medicine, Chang Gung University, Tao-Yuan, Taiwan; Graduate Institute of Clinical Medical Sciences, Chang Gung University, Tao-Yuan, Taiwan. Electronic address: chihchung@cgmh.org.tw.

Abstract

BACKGROUND:

Corrected flow time (FTc) has been utilized as preload indicator in recent literature. Accurate estimation of preload status during living donor liver donation (LDLD) is important due to fluid restriction. We evaluate the effectiveness of FTc as a surrogate of preload indicator during LDLD.

MATERIALS AND METHODS:

Twenty-five patients undergoing LDLD were enrolled in the study. Administration of intravenous fluid was restricted before lobectomy was performed. After the organ was harvest, fluid challenge with 500 mL of Voluven (130/0.42, Fresenius, Friedberg, Germany) was performed. Stroke volume (SV) was measured with ultrasonic cardiac output monitor (USCOM; USCOM Pty, Ltd, Sydney, Australia) before and after the fluid challenge. The FTc value obtained with USCOM before fluid challenge was recorded. Fluid responsiveness was defined as an increase in SV of more than 15%. Receiver operating characteristic (ROC) curve was performed.

RESULTS:

The area under ROC curve was 0.9. The optimal cutoff FTc value was 340 milliseconds during LDLD.

CONCLUSIONS:

FTc is a noninvasive, easily obtainable, and essentially good preload indicator during LDLD.

Copyright © 2014 Elsevier Inc. All rights reserved.

PMID:
24767320
[PubMed - indexed for MEDLINE]
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