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Molecules. 2014 Apr 23;19(4):5325-47. doi: 10.3390/molecules19045325.

Rice bran feruloylated oligosaccharides activate dendritic cells via Toll-like receptor 2 and 4 signaling.

Author information

  • 1Institute of Biomedical Science, National Chung-Hsing University, Taichung 402, Taiwan. lincc@dragon.nchu.edu.tw.
  • 2Department of Food Science, National Penghu University of Science and Technology, Makung City, Penghu Hsien 880, Taiwan. huahan@gms.npu.edu.tw.
  • 3Department of Food Science, National Pingtung University of Science and Technology, Pingtung 912, Taiwan. chenyk@mail.npust.edu.tw.
  • 4Department of Food Science, National Penghu University of Science and Technology, Makung City, Penghu Hsien 880, Taiwan. demonsandy@gmail.com.
  • 5Transplant Medicine & Surgery Research Centre, Changhua Christian Hospital, Changhua 500, Taiwan. lillian1109ms@yahoo.com.tw.
  • 6Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu 310, Taiwan. I-HorngPan@itri.org.tw.
  • 7Department of Medical Research and Education, Taichung Veterans General Hospital, Taichung, 407, Taiwan. chchen1@dragon.nchu.edu.tw.
  • 8Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan. chchen1@dragon.nchu.edu.tw.
  • 9Institute of Biomedical Science, National Chung-Hsing University, Taichung 402, Taiwan.

Abstract

This work presents the effects of feruloylated oligosaccharides (FOs) of rice bran on murine bone marrow-derived dendritic cells (BMDCs) and the potential pathway through which the effects are mediated. We found that FOs induced phenotypic maturation of DCs, as shown by the increased expression of CD40, CD80/CD86 and MHC-I/II molecules. FOs efficiently induced maturation of DCs generated from C3H/HeN or C57BL/6 mice with normal toll-like receptor 4 (TLR-4) or TLR-2 but not DCs from mice with mutated TLR4 or TLR2. The mechanism of action of FOs may be mediated by increased phosphorylation of ERK, p38 and JNK mitogen-activated protein kinase (MAPKs) and increased NF-kB activity, which are important signaling molecules downstream of TLR-4 and TLR-2. These data suggest that FOs induce DCs maturation through TLR-4 and/or TLR-2 and that FOs might have potential efficacy against tumor or virus infection or represent a candidate-adjuvant approach for application in immunotherapy and vaccination.

PMID:
24762969
[PubMed - indexed for MEDLINE]
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