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Thromb Res. 2014 May;133 Suppl 1:S3-5. doi: 10.1016/j.thromres.2014.03.002.

Adoptive transfer method to study platelet function in mouse models of disease.

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  • 1Department of Biochemistry/Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: bergmeie@email.unc.edu.
  • 2McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Abstract

Platelets play an important role in many physiological and pathological situations. However, the molecular mechanisms by which platelets contribute to health and disease are often ill-defined. One of the limiting factors to these studies is a fast but reliable method to generate animals with platelet-specific signaling defects. We here review recent approaches to establish an adoptive platelet transfer model in mice.

Copyright © 2014 Elsevier Ltd. All rights reserved.

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