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Chem Commun (Camb). 2014 Jun 1;50(43):5790-2. doi: 10.1039/c4cc01440e. Epub 2014 Apr 23.

A highly sensitive and reductant-resistant fluorescent probe for nitroxyl in aqueous solution and serum.

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  • 1Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Collaborative Innovation Center for Molecular Engineering and Theranostics, Hunan University, Changsha 410082, China. xbzhang@hnu.edu.cn tan@chem.ufl.edu.


A novel coumarin-based fluorescent probe, P-CM, for quantitative detection of nitroxyl (HNO) was developed. P-CM exhibits a selective response to HNO over other biological reductants and was also applied for quantitative detection of HNO in bovine serum with satisfactory results.

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