Bitter taste receptor (TAS2R) agonists inhibit IgE-dependent mast cell activation

J Allergy Clin Immunol. 2014 Aug;134(2):475-8. doi: 10.1016/j.jaci.2014.02.029. Epub 2014 Apr 19.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chloroquine / pharmacology*
  • Dextromethorphan / pharmacology*
  • Fetal Blood / cytology
  • Fetal Blood / immunology
  • Gene Expression Regulation / drug effects
  • Histamine / biosynthesis
  • Humans
  • Immunoglobulin E / immunology*
  • Mast Cells / cytology
  • Mast Cells / drug effects*
  • Mast Cells / immunology
  • Noscapine / pharmacology*
  • Prostaglandin D2 / antagonists & inhibitors
  • Prostaglandin D2 / metabolism
  • Protein Isoforms / agonists
  • Protein Isoforms / genetics
  • Protein Isoforms / immunology
  • Quaternary Ammonium Compounds / pharmacology*
  • Receptors, G-Protein-Coupled / agonists*
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, G-Protein-Coupled / immunology
  • Receptors, IgE / genetics
  • Receptors, IgE / immunology

Substances

  • Protein Isoforms
  • Quaternary Ammonium Compounds
  • Receptors, G-Protein-Coupled
  • Receptors, IgE
  • TAS2R1 protein, human
  • Immunoglobulin E
  • denatonium
  • Dextromethorphan
  • Histamine
  • Chloroquine
  • Noscapine
  • Prostaglandin D2