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Pediatr Blood Cancer. 2014 Oct;61(10):1877-9. doi: 10.1002/pbc.25055. Epub 2014 Apr 19.

Burkitt lymphoma and Ewing sarcoma in a child with Williams syndrome.

Author information

  • 1Tampere Center for Child Health Research, University of Tampere Medical School and Tampere University Hospital, Tampere, Finland.

Abstract

Williams syndrome (WS) is a relatively rare multisystem neurodevelopmental disorder caused by a hemizygous deletion of contiguous genes on chromosome 7q11.23. Although WS does not predispose carriers to cancers, alterations of chromosome 7 are common in several human neoplasms. We report here a patient with WS and two different cancers, Burkitt lymphoma and Ewing sarcoma. Array-CGH analysis of the patient blood revealed a constitutive 1.4 million base pair deletion at 7q11.23, compatible with WS diagnosis.

© 2014 Wiley Periodicals, Inc.

KEYWORDS:

Burkitt lymphoma; Ewing sarcoma; Williams syndrome; chromosomal translocation

PMID:
24753445
[PubMed - indexed for MEDLINE]
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