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Chem Commun (Camb). 2014 Jun 7;50(45):5967-9. doi: 10.1039/c4cc01005a. Epub 2014 Apr 22.

Design of tetraplex specific ligands: cyclic naphthalene diimide.

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  • 1Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan. shige@che.kyutech.ac.jp.


Cyclic naphthalene diimide 1 bound to hybrid-type tetraplex DNA from 5'-AGGG(TTAGGG)3-3' (K = 8.6 × 10(6) M(-1)) with 260-fold greater affinity than binding to a double stranded oligonucleotide consisting of 5'-GGG AGG TTT CGC-3' and 3'-CCC TCC AAA GCG-5' (nK = 3.3 × 10(4) M(-1)) with 0.5 μM of IC50 for telomerase activity.

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