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Chem Commun (Camb). 2014 Jun 1;50(43):5741-4. doi: 10.1039/c4cc02011a. Epub 2014 Apr 22.

Detection of Aβ plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe.

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  • 1Department of Chemistry, Korea University, Seoul 136-701, Korea.


We herein report a fluorescence probe 1 capable of detecting water-soluble oligomeric Aβ aggregates and Aβ fibrils. Upon injection into Aβ42-challenged mouse brains, probe 1 shows increased fluorescence intensity, indicating its facile binding to extracellular Aβ fibrils in brain tissues.

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