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Saudi Med J. 2014 Apr;35(4):329-35.

Study of the correlationship link between microRNAs and nasopharyngeal carcinoma.

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  • 1Oncology Department, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People's Hospital, 183 Yiling Road, Yichang 443003, China. Tel. +86 (717) 6487360. Fax. +86 (717) 6481291. E-mail: xuxinhua@medmail.com.cn.

Abstract

Nasopharyngeal carcinoma (NPC) is a polygenic disease related to a variety of factors. With the development of the microRNAs (miRNAs) technique, researchers found a close link between miRNAs and NPC. Differentially expressed miRNAs exist in NPC and normal nasopharyngeal tissues; radiotherapy and chemotherapy also affect the expression of miRNAs in NPC tissues. Further studies showed that dysregulation and ectopic expression of miRNAs were involved in the occurrence and development of NPC by affecting the expression of oncogenes or tumor suppressor genes, or acting on relevant signal transduction pathways. It is of great significance to investigate the miRNAs related to the occurrence and development of NPC for the prevention and treatment of NPC.

PMID:
24749128
[PubMed - indexed for MEDLINE]
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