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BMJ Case Rep. 2014 Apr 19;2014. pii: bcr2013203352. doi: 10.1136/bcr-2013-203352.

Severe depression masquerading as Creutzfeldt-Jakob disease.

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  • 1Institute of Neurological Sciences, Prince of Wales Hospital, Sydney, Australia.


We report a case of melancholic depression with catatonic features presenting as a rapidly progressive organic brain syndrome, initially thought to be probable Creutzfeldt-Jakob disease. The case highlights the fundamental importance of thorough exclusion of treatable pathology masquerading as an irreversible syndrome.

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