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PLoS Pathog. 2014 Apr 17;10(4):e1004038. doi: 10.1371/journal.ppat.1004038. eCollection 2014.

Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria.

Author information

  • 1SciLifeLab Stockholm, School of Biotechnology, KTH-Royal Institute of Technology, Stockholm, Sweden.
  • 2Division of Parasitology, Medical Research Council National Institute for Medical Research, London, United Kingdom.
  • 3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • 4Department of Paediatrics, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria; Department of Haematology, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria; Childhood Malaria Research Group, University College Hospital, Ibadan, Nigeria.
  • 5Department of Paediatrics, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria.
  • 6Department of Paediatrics, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria; Childhood Malaria Research Group, University College Hospital, Ibadan, Nigeria.
  • 7Department of Haematology, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria; Childhood Malaria Research Group, University College Hospital, Ibadan, Nigeria.
  • 8Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
  • 9Division of Parasitology, Medical Research Council National Institute for Medical Research, London, United Kingdom; Department of Paediatrics, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria; Department of Haematology, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria; Childhood Malaria Research Group, University College Hospital, Ibadan, Nigeria.
  • 10Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • 11Division of Parasitology, Medical Research Council National Institute for Medical Research, London, United Kingdom; Department of Paediatrics, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria; Department of Haematology, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria; Childhood Malaria Research Group, University College Hospital, Ibadan, Nigeria; Brighton & Sussex Medical School, Sussex University, Brighton, United Kingdom.

Abstract

Systemic inflammation and sequestration of parasitized erythrocytes are central processes in the pathophysiology of severe Plasmodium falciparum childhood malaria. However, it is still not understood why some children are more at risks to develop malaria complications than others. To identify human proteins in plasma related to childhood malaria syndromes, multiplex antibody suspension bead arrays were employed. Out of the 1,015 proteins analyzed in plasma from more than 700 children, 41 differed between malaria infected children and community controls, whereas 13 discriminated uncomplicated malaria from severe malaria syndromes. Markers of oxidative stress were found related to severe malaria anemia while markers of endothelial activation, platelet adhesion and muscular damage were identified in relation to children with cerebral malaria. These findings suggest the presence of generalized vascular inflammation, vascular wall modulations, activation of endothelium and unbalanced glucose metabolism in severe malaria. The increased levels of specific muscle proteins in plasma implicate potential muscle damage and microvasculature lesions during the course of cerebral malaria.

PMID:
24743550
[PubMed - indexed for MEDLINE]
PMCID:
PMC3990714
Free PMC Article
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