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Oncotarget. 2014 Apr 15;5(7):1701-52.

Pathways and therapeutic targets in melanoma.

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  • 1Cancer Commons, Palo Alto, CA, USA.

Abstract

This review aims to summarize the current knowledge of molecular pathways and their clinical relevance in melanoma. Metastatic melanoma was a grim diagnosis, but in recent years tremendous advances have been made in treatments. Chemotherapy provided little benefit in these patients, but development of targeted and new immune approaches made radical changes in prognosis. This would not have happened without remarkable advances in understanding the biology of disease and tremendous progress in the genomic (and other "omics") scale analyses of tumors. The big problems facing the field are no longer focused exclusively on the development of new treatment modalities, though this is a very busy area of clinical research. The focus shifted now to understanding and overcoming resistance to targeted therapies, and understanding the underlying causes of the heterogeneous responses to immune therapy.

PMID:
24743024
[PubMed - in process]
PMCID:
PMC4039128
Free PMC Article
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