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Prenat Diagn. 1989 Jan;9(1):27-30.

Triploid fetus: an important consideration in the evaluation of very high maternal serum alpha-fetoprotein.

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  • 1Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.


Two patients referred for evaluation of very high maternal serum alpha-fetoprotein (10-20 multiples of the median) were carrying triploid fetuses with placentas showing features of partial hydatidiform mole. The diagnosis of fetal triploidy should be considered when there is a very high maternal serum alpha-fetoprotein and no ultrasound evidence of open neural tube defect, ventral wall defect, or any other explanation. Therefore, chromosomal analysis of amniotic fluid cells in such cases is essential.

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