Long-term mortality in a cohort of home-dwelling elderly with mild Alzheimer's disease and Lewy body dementia

Dement Geriatr Cogn Disord. 2014;38(3-4):161-9. doi: 10.1159/000358051. Epub 2014 Apr 8.

Abstract

Objective: To study mortality in subjects with mild dementia in Norway with a special focus on patients with Lewy body dementia (LBD) compared to Alzheimer's disease (AD).

Methods: All referrals of mild dementia patients to dementia clinics in western Norway from March 2005 to March 2007 were included and followed until December 2012. Diagnoses were based on a comprehensive standardized assessment program.

Results: Of 209 patients, 137 (66%) had AD and 53 (25%) had LBD. Dementia was associated with increased mortality (standardized mortality ratio = 1.8, AD 1.5, LBD 2.6). The median survival time was 6.2 years (95% CI 5.4-6.9). Predictors of mortality were age at diagnosis (HR 1.1 per year) and LBD diagnosis (HR 2.4).

Conclusion: Dementia patients had an increased mortality, particularly those with LBD.

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / mortality*
  • Cohort Studies
  • Female
  • Humans
  • Lewy Body Disease / mortality*
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Norway
  • Residence Characteristics
  • Survival Rate