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Mult Scler. 2014 Oct;20(12):1593-601. doi: 10.1177/1352458514528758. Epub 2014 Apr 14.

Beta2-adrenergic agonist use and the risk of multiple sclerosis: a total population-based case-control study.

Author information

  • 1Neurological Institute, Taipei Veterans General Hospital and National Yang-Ming University, Taiwan.
  • 2Kaohsiung Medical University Hospital, Kaohsiung Medical University, Taiwan/Pingtung Hospital, Ministry of Health and Welfare, Taiwan.
  • 3Kaohsiung Medical University, No. 100, Shih-Chuan 1st Rd., Sanmin District, Kaohsiung City 80708, Taiwan (R.O.C.) charles@kmu.edu.tw.

Abstract

OBJECTIVE:

The aim of this study was to investigate whether the use of fenoterol, a beta2-adrenergic agonist, was associated with multiple sclerosis (MS) risk by conducting a total population-based case-control study in Taiwan.

METHODS:

A total of 578 patients with newly diagnosed MS who had a severely disabling disease (SDD) certificate between January 1, 2002 and December 1, 2008 comprised the case group. These cases were compared with 2890 gender-, age-, residence-, and insurance premium-matched controls. Fenoterol use was analyzed using a conditional logistic regression model that controlled for asthma, chronic obstructive pulmonary disease (COPD), salbutamol and steroid use.

RESULTS:

Compared with the group of people who did not use fenoterol, the adjusted odds ratios were 0.67 (95% confidence interval (CI) = 0.48-0.93, p = 0.016) for the group prescribed fenoterol below 2.25 cumulative defined daily dose (cDDD) and 0.49 (95% CI = 0.33-0.71, p < 0.001) for the group with a cumulative fenoterol use of more than 2.25 cDDD. The dose-response relationship was similar within the non-asthma patients. The associations were similar between males and females, but differences between age groups were observed.

CONCLUSIONS:

The results of this study suggest that fenoterol use may reduce the risk of MS.

© The Author(s), 2014.

KEYWORDS:

Multiple sclerosis; case-control study; fenoterol

PMID:
24732071
[PubMed - indexed for MEDLINE]
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