Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Rheumatol. 1989 Apr;16(4):489-93.

Liver biopsy findings in patients with rheumatoid arthritis undergoing longterm treatment with methotrexate.

Author information

  • 1Department of Rheumatology, Evangelisches Fachkrankenhaus, Ratingen, West Germany.

Abstract

Ten histological criteria were evaluated semiquantitatively in the liver biopsies of 60 patients with rheumatoid arthritis (RA) before initiation of methotrexate (MTX) and were compared with 40 biopsies taken during MTX treatment (mean cumulative dose 1.322 mg). Mesenchymal changes (Kupffer cell proliferation, portal tract infiltration) and parenchymal alterations (nuclear variability, ballooning, fatty infiltration) were very common without statistically significant difference between the 2 groups. Slight periportal and/or portal fibrosis was present in 25% of patients without statistical difference between groups. Central fibrosis occurred in 13.5-12.5%. We conclude that liver abnormalities in RA are not related to MTX treatment.

Comment in

PMID:
2473207
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk