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Complement Inflamm. 1989;6(3):166-74.

Monoclonal antibodies against components of the classical pathway of complement.

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  • 1Institute of Medical Microbiology, Johannes Gutenberg University, Mainz, FRG.


Activation of the classical pathway of complement involves several binding and enzymatic cleavage processes. Binding and enzymatic activation results in the appearance of new structures in the individual components. This report describes the different activation steps for C1q, C1r, C1s, C4 and C2 and summarizes monoclonal antibodies reported so far which recognize either conserved epitopes or activation-dependent epitopes with particular emphasis on neoepitopes occurring during the activation cascade.

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