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Arch Immunol Ther Exp (Warsz). 2014 Oct;62(5):369-84. doi: 10.1007/s00005-014-0287-9. Epub 2014 Apr 12.

Ghrelin gene products in acute and chronic inflammation.

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  • 1Departmant of Health Sciences, Università del Piemonte Orientale "Amedeo Avogadro", Novara, Italy.


Ghrelin gene products--the peptides ghrelin, unacylated ghrelin, and obestatin--have several actions on the immune system, opening new perspectives within neuroendocrinology, metabolism and inflammation. The aim of this review is to summarize the available evidence regarding the less known role of these peptides in the machinery of inflammation and autoimmunity, outlining some of their most promising therapeutic applications.

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