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Radiat Oncol J. 2014 Mar;32(1):1-6. doi: 10.3857/roj.2014.32.1.1. Epub 2014 Mar 27.

Treatment outcome of ductal carcinoma in situ patients treated with postoperative radiation therapy.

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  • 1Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.
  • 2Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea. ; Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Korea.
  • 3Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.

Abstract

PURPOSE:

To evaluate the outcome of ductal carcinoma in situ (DCIS) patients who underwent surgery followed by radiation therapy (RT).

MATERIALS AND METHODS:

We retrospectively reviewed 106 DCIS patients who underwent surgery followed by postoperative RT between 1994 and 2006. Ninety-four patients underwent breast-conserving surgery, and mastectomy was performed in 12 patients due to extensive DCIS. Postoperative RT was delivered to whole breast with 50.4 Gy/28 fx. Tumor bed boost was offered to 7 patients (6.6%). Patients with hormonal receptor-positive tumors were treated with hormonal therapy.

RESULTS:

The median follow-up duration was 83.4 months (range, 33.4 to 191.5 months) and the median age was 47.8 years. Ten patients (9.4%) had resection margin <1 mm and high-grade and estrogen receptor-negative tumors were observed in 39 (36.8%) and 20 (18.9%) patients, respectively. The 7-year ipsilateral breast tumor recurrence (IBTR)-free survival rate was 95.3%. Resection margin (<1 or ≥1 mm) was the significant prognostic factor for IBTR in univariate and multivariate analyses (p < 0.001 and p = 0.016, respectively).

CONCLUSION:

Postoperative RT for DCIS can achieve favorable treatment outcome. Resection margin was the important prognostic factor for IBTR in the DCIS patients who underwent postoperative RT.

KEYWORDS:

DCIS; IBTR; Postoperative RT

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