When PRRs collide: mincle meddles with dectin and toll

Cell Host Microbe. 2014 Apr 9;15(4):397-9. doi: 10.1016/j.chom.2014.03.013.

Abstract

Pattern recognition receptors (PRR) promote pathogen eradication and shape adaptive immunity. Although evidence suggests PRRs can antagonize each other, few detailed mechanisms are known. Wevers et al. (2014) uncover a mechanism of PRR antagonism where fungal-induced Mincle signaling suppresses IL-12 transcription induced by other PRRs and thereby abates antifungal immunity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Humans
  • Interleukin-12 Subunit p35 / biosynthesis*
  • Lectins, C-Type / immunology*
  • Receptors, Immunologic / immunology*
  • Saccharomycetales / immunology*

Substances

  • CLEC4D protein, human
  • IL12A protein, human
  • Interleukin-12 Subunit p35
  • Lectins, C-Type
  • Receptors, Immunologic
  • dectin 1